| Registro completo |
| Provedor de dados: |
Ciência Rural
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| País: |
Brazil
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| Título: |
Immunohistochemical expression of B and T-lymphocytes and TGF-β in experimentally transplanted canine venereal tumor
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| Autores: |
Silveira,Ana Carolina Trompieri
Gerardi,Daniel
Mouro,Juliana Vitti
Costa,Mirela Tinucci
Alessi,Antonio Carlos
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| Data: |
2009-07-01
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| Ano: |
2009
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| Palavras-chave: |
Lymphocytes
TVT
Immunohistochemistry
Dog
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| Resumo: |
The tumor/host relationship may have a determining role in the progression or remission of a tumor. Greater infiltration of leukocytes into tumors has been associated with a better prognosis, although controversy regarding whether these cells have a central role in antitumor immunity still exists. Canine transmissible venereal tumor (TVT) is an experimentally transplantable type of tumor that has been used as an experimental model for the tumor/host relationship. The aim of this study was to evaluate the infiltration of T-lymphocytes (CD3, CD4, CD8) and B lymphocytes (CD79-α) and the expression of the cytokine TGF-β in TVT, by means of immunohistochemistry (ABC method). The experimental tumors were composed of puppies that developed TVT after transplantation, in the progression (n=8) (Group 1a), latency (n=8) (Group 1b) and regression (n=8) (Group 1c) phases of the tumor. CD3+ T-lymphocytes predominated in the progression and regression phases, in relation to the latency phase. CD4+ and ¹CD8+ T-lymphocytes were predominant in the progression phase, and with lower expression in the regression phase. The greatest quantities of B-lymphocytes were in the regression phase, with restricted expression in the progression phase. TGF-β was expressed equally in the phases of the transplanted TVT.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000400029
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| Editor: |
Universidade Federal de Santa Maria
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| Relação: |
10.1590/S0103-84782009005000025
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| Formato: |
text/html
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| Fonte: |
Ciência Rural v.39 n.4 2009
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| Direitos: |
info:eu-repo/semantics/openAccess
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